Cst fam134b
WebFeb 21, 2024 · FAM134B controls ER turnover by specific binding to microtubule-associated protein 1 light chain 3B (MAP1LC3B), which in turn binds to the phagophore membrane … WebFAM134B contains a conserved LC3 interacting domain (LIR) that facilitates binding to LC3 and GABARAP family members and targets impaired ER to the autophagosome for degradation by ER-phagy (2). ... Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products ...
Cst fam134b
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WebJan 13, 2024 · FAM134B forms oligomers that are required for ER membrane scission and ER-phagy A. Endogenous FAM134B forms oligomers. FAM134B knockout (KO) or wild-type (WT) 293T cells were treated with 1 μM of Thapsigargin (Tg) for different time, and the cell lysates were prepared and analyzed by Western blot. WebOct 28, 2024 · In contrast, FAM134B may rather act as a tumor suppressor, since FAM134B mutations have been frequently found in colorectal adenocarcinoma, and esophageal squamous cell carcinoma [41, 43, 73].
WebPolyclonal Antibody for studying FAM134B. Cited in 3 publications. Validated for Western Blotting, Immunoprecipitation. Highly specific and rigorously validated in-house, FAM134B Antibody (CST #61011) is … WebFam134b, supplied by Abcam, used in various techniques. Bioz Stars score: 92/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
WebApr 11, 2024 · Crucially, to confirm that endogenous FAM134B flux follows a similar trend to the overexpressed reporter, we looked at FAM134B localization in PDAC cells upon BafA1 treatment (Figure 4D). Indeed, FAM134B puncta accumulation after autophagy block indicates high basal turnover rate of the receptor in line with our observation with the … WebOct 13, 2015 · Mutant FAM134B proteins that cause sensory neuropathy in humans (HSAN2B; 613115) are unable to act as ER-phagy receptors. Consistently, disruption of Fam134b in mice causes expansion of the ER, inhibits ER turnover, sensitizes cells to stress-induced apoptotic cell death, and leads to degeneration of sensory neurons.
WebApr 18, 2024 · Here we report that in cancer cells, hypoxia-induced ER stress activates ER-phagy through the ER-phagy receptor FAM134B. Upon hypoxic stress, FAM134B is included in a complex with the ER chaperone ...
WebJul 8, 2024 · The endoplasmic reticulum (ER) autophagy receptor FAM134B contains an LIR motif that can bind to Atg8s, but whether it can differentially bind to the two … songs by lee greenwood god bless the usaWebDec 14, 2024 · FAM134B has also been associated with different cancers, although its exact role remains elusive. We report here that the FAM134B gene encodes not one but … songs by led zeppelin battle of evermoreWebMar 29, 2024 · Fam134b is an oncogene that plays a crucial role in hepatocellular carcinoma via the Akt signaling pathway. FAM134B could play crucial roles in the … songs by lifehouse most popularWebMay 17, 2024 · Four ER-resident proteins (FAM134B, CCPG1, SEC62, and RTN3) have been identified as ER-resident cargo receptors, which contain LC3-interacting regions. In this study, we identified an N … songs by leeland the bandWebJun 23, 2024 · The recent identification of FGF/TFEB/FAM134B signaling event represents the first study that implicates the role of TFEB in ER-phagy and its physiological relevance during skeletal development in ... small fireplace heater and tv standWebRespond to Notice CP134B. First, order the Account Transcripts for ALL time periods from the IRS. Then compare your deposits with the Account Transcripts. If you use a payroll … songs by les paul and mary ford on u tubeWebFeb 19, 2024 · FAM134B was the first and so far the best characterized ER-phagy receptor (Khaminets et al, 2015). FAM134B is an intramembrane ER-resident protein that contains a LIR domain and a reticulon homology domain (RHD), which consists of two membrane-embedded hydrophobic regions bridged by a flexible cytoplasmic linker ... small fireplace heaters amazon