Efficient synthesis of scutellarein

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August undefined, 2024

WebA practical and economical five-step synthesis of the flavone scutellarein has been achieved in 60% overall yield using the available and cheap 2,6-dimethoxy-1,4 … Webpractical method for the synthesis of scutellarein under mild reaction conditions is still in demand. Results and discussion Our practical and economical five-step synthesis of scutellarein 1 is shown in Scheme 2. It was achieved in approximately 60% overall yield using the cheap 2,6-dimethoxy-1,4-benzoquinone as the starting material.

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WebMar 1, 2024 · An experimentally simple and efficient synthesis of 2-alkynyl-5-methoxy-1,4-benzoquinones is described. This involves the 1,2-addition of lithium acetylides to 4,5-dimethoxy-1,2-benzoquinone to... WebScutellarin (1) is readily converted in vivo, therefore, synthetic methods for the construction of its metabolites will be very important in the near future. In this work, an efficient and … georgia lakefront homes for sale waterfront

An Efficient Chemical Synthesis of Scutellarein: An

WebAbstract: In this paper, a new and efficient synthesis of 6-O-methylscutellarein (3), the major metabolite of the natural medicine scutellarin, is reported. Two hydroxyl groups at … WebJul 26, 2016 · The phenolic hydroxyl groups of scutellarein provide important ‘synthetic handles’ for the structural modification of scutellarein and facilitate the design and synthesis of novel prodrugs with the potential for improved bioactivity and … WebTherefore, the present study focused on establishing an efficient route for the synthesis of scutellarein by hydrolyzing scutellarin. The in vitro antioxidant activities of scutellarein were evaluated by measuring its scavenging capacities toward DPPH, ABTS + • , • OH free radicals and its protective effect on H2O2-induced cytotoxicity in ... georgia land bank association

A New and Efficient Synthesis of 6-O-Methylscutellarein, the …

Permeability of novel 4′-N-substituted (aminomethyl) benzoate-7 ...

WebScutellarein is a component of Scutellaria, recently known as a potent cytotoxic agent on human leukaemia cells. The aim of this study was the synthesis of scutellarein and its methylated derivative. The new features are the innovating method to afford flavones … Webscutellarein pretreatment could ameliorate rat brain injury after ischemia in vivo, with better activity than scutellarin [10]. There is little scutellarein in E. breviscapus compared with large amounts of scutellarin [10]. Frakas [11] and Cui [12] had already completed the total synthesis of scutellarein, but the route was long and the yield ... georgia land lotteryWebOct 19, 2011 · Scutellarein is a component of Scutellaria, recently known as a potent cytotoxic agent on human leukaemia cells. The aim of this study was the synthesis of … georgia lake rental secluded swimming

"WebMar 1, 2024 · The scarce scutellarein aglycon and, in particular, the glycuronyl phenolic linkage which is notorious for unsatisfactory formation efficiency due to the diminished … " - Efficient synthesis of scutellarein

Efficient synthesis of scutellarein

Efficient Chemical Synthesis of a Scutellarein Derivative Containing ...

WebFeb 25, 2016 · Synthesis. 1- (6-Hydroxy-2,3,4-trimethoxyphenyl)ethanone ( 4 ): To a stirring solution of 3 (10 g, 54.5 mmol) in BF 3 ·Et 2 O (25 mL) was added CH 3 COOH (15 mL). After stirring under N 2 atmosphere at 85 °C for 2.5 h, the reaction mixture was allowed to warm to room temperature. Then ice water (50 mL) was added slowly. WebOct 23, 2012 · Scutellarin (40,5,6-trihydroxyflavone-7-glucuronide), primarily absorbed in the form of its hydrolyzed metabolite scutellarein (5,6,7,4′-tetrahydroxyflavone), has been validated to accelerate...

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WebAbstract: In this paper, a new and efficient synthesis of 6-O-methylscutellarein (3), the major metabolite of the natural medicine scutellarin, is reported. Two hydroxyl groups at ... then 6-O-methyl-scutellarein (3) was produced in high yield after methylation of the hydroxyl group at C-6 and subsequent deprotection of the two methyl ether groups. WebOct 19, 2011 · Europe PMC is an archive of life sciences journal literature.

WebFeb 25, 2016 · In summary, we have developed an efficient chemical synthesis of scutellarein (2) in high yield in only four steps. This strategy relies on acetylation, … WebFeb 1, 2024 · Scutellarin is the major active flavonoid extracted from the traditional Chinese herbal medicine Erigeron breviscapus (Vant.) Hand-Mazz., which is widely used in China. Recently, accumulating...

WebMay 1, 2024 · In this study, we designed, synthesized and evaluated a series of scutellarin and scutellarein-N,N-bis-substituted carbamate-l-amino acid derivatives as multifunctional therapeutic agents for the treatment of Alzheimer's disease (AD).Compounds containing scutellarein as the parent nucleus (6a–l) had good inhibitory activity against acetyl … WebThis kind of scutellarein derivative (3) could be an efficient agent for ischemic cerebrovascular disease treatment. Open in a separate window. Scheme 1. The route of the synthesis of scutellarein derivate (3). (a) H 2 SO 4, EtOH, 120 °C, 48 h, 17.3%; (b) H …

WebScutellarein is a component of Scutellaria, recently known as a potent cytotoxic agent on human leukaemia cells. The aim of this study was the synthesis of scutellarein and its …

WebJun 2, 2016 · Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant. For research use only. We do not sell to patients. Scutellarein Chemical Structure CAS No. : 529-53-3 Get it February 27 … georgia lake homes near atlantaWebIn summary, we have developed an efﬁcient chemical synthesis of scutellarein (2) in high yield in only four steps. This strategy relies on acetylation, aldolization, cyclization and … christian marriage bedWebFeb 25, 2016 · Scutellarein (2), which is an important in vivo metabolite of scutellarin (1), was synthesized from 3,4,5-trimethoxyphenol (3) in high yield in four steps. This … georgia land lottery 1805WebSep 6, 2012 · In summary, an efficient route for the synthesis of scutellarein by hydrolyzing scutellarin was reported. Essential to the synthesis was the use of H 2 SO 4 in 90% ethanol under a N 2 … christian marriage advice intimacyWebScutellarin (1) is readily converted in vivo, therefore, synthetic methods for the construction of its metabolites will be very important in the near future. In this work, an efficient and first synthetic method for 6-O-methyl- scutellarein (3), one metabolite of … christian marriage and family articlesWebScutellarein C15H10O6 CID 5281697 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... georgia landlord and tenant lawsWebOct 19, 2011 · Europe PMC is an archive of life sciences journal literature. georgia lakes and rivers map